Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Neurobehavioral Manifestations'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Nervous System Diseases
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • Aspartylglucosaminuria (GDGDB) [AGA]
                • Alpha-mannosidosis (GDGDB) [MAN2B1]
                • Beta-mannosidosis (GDGDB) [MANBA]
                • Mucolipidosis II (alpha/beta) (GDGDB) [GNPTAB]
                • Sanfilippo syndrome A (GDGDB) [SGSH]
                • Sanfilippo syndrome B (GDGDB) [NAGLU]
                • Sanfilippo syndrome C (GDGDB) [HGSNAT]
                • Sanfilippo syndrome D (GDGDB) [GNS]
                • Tay-Sachs disease (GDGDB) [HEXA]
                • Sandhoff disease (GDGDB) [HEXB]
                • Multiple sulfatase deficiency (GDGDB) [SUMF1]
                • Metachromatic leukodystrophy (GDGDB) [ARSA]
                • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
                • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
                • Farber Lipogranulomatosis (GDGDB) [ASAH1]
                  • Farber Lipogranulomatosis, type 5 [ASAH1]
            • Learning Disorders
              • Aspartylglucosaminuria (GDGDB) [AGA]
              • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Schindler disease, type I (GDGDB) [NAGA]
              • Mucolipidosis III (alpha/beta) (GDGDB) [GNPTAB]
              • Hurler syndrome (GDGDB) [IDUA]
              • Hurler-Scheie syndrome (GDGDB) [IDUA]
              • Sanfilippo syndrome A (GDGDB) [SGSH]
              • Sanfilippo syndrome B (GDGDB) [NAGLU]
              • Sanfilippo syndrome C (GDGDB) [HGSNAT]
              • Sanfilippo syndrome D (GDGDB) [GNS]
              • Metachromatic leukodystrophy (GDGDB) [ARSA]
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Niemann-Pick disease, type A (GDGDB) [SMPD1]
              • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
              • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
          • Intellectual Disability
            • Aspartylglucosaminuria (GDGDB) [AGA]
            • Fucosidosis (GDGDB) [FUCA1]
            • Alpha-mannosidosis (GDGDB) [MAN2B1]
            • Beta-mannosidosis (GDGDB) [MANBA]
            • Sialidosis (GDGDB) [NEU1]
              • Sialidosis type II [NEU1]
            • Schindler disease, type I (GDGDB) [NAGA]
            • Schindler disease, type II (GDGDB) [NAGA]
            • Galactosialidosis (GDGDB) [CTSA]
            • Mucolipidosis III (alpha/beta) (GDGDB) [GNPTAB]
            • Hurler syndrome (GDGDB) [IDUA]
            • Hurler-Scheie syndrome (GDGDB) [IDUA]
            • Sanfilippo syndrome A (GDGDB) [SGSH]
            • Sanfilippo syndrome B (GDGDB) [NAGLU]
            • Sanfilippo syndrome C (GDGDB) [HGSNAT]
            • Sanfilippo syndrome D (GDGDB) [GNS]
            • Mucopolysaccharidosis VII (GDGDB) [GUSB]
            • GM1-gangliosidosis, type I (GDGDB) [GLB1]
            • GM1-gangliosidosis, type II (GDGDB) [GLB1]
            • GM1-gangliosidosis, type III (GDGDB) [GLB1]
            • Tay-Sachs disease (GDGDB) [HEXA]
            • Sandhoff disease (GDGDB) [HEXB]
            • Fabry disease (GDGDB) [GLA]
            • Gaucher disease, type II (GDGDB) [GBA]
            • Gaucher disease, type III (GDGDB) [GBA]
            • Gaucher disease, atypical, due to saposin C deficiency (GDGDB) [PSAP]
            • Krabbe disease (GDGDB) [GALC]
            • Metachromatic leukodystrophy (GDGDB) [ARSA]
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
            • Niemann-Pick disease, type A (GDGDB) [SMPD1]
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
            • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
            • Farber Lipogranulomatosis (GDGDB) [ASAH1]
            • Mental Retardation, X-Linked
              • Mucolipidosis II (alpha/beta) (GDGDB) [GNPTAB]
          • Perceptual Disorders
            • Hallucinations
              • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Metachromatic leukodystrophy (GDGDB) [ARSA]
                • Metachromatic leukodystrophy, adult form [ARSA]