Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Eye Diseases'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Eye Diseases
      • Corneal Diseases
        • Corneal Opacity
          • Mucolipidosis III (alpha/beta) (GDGDB) [GNPTAB]
          • Hurler syndrome (GDGDB) [IDUA]
          • Hurler-Scheie syndrome (GDGDB) [IDUA]
          • Scheie syndrome (GDGDB) [IDUA]
          • Morquio syndrome A (GDGDB) [GALNS]
          • Morquio syndrome B (GDGDB) [GLB1]
          • Mucopolysaccharidosis VI (GDGDB) (GDGDB) [ARSB]
          • Mucopolysaccharidosis VII (GDGDB) [GUSB]
          • GM1-gangliosidosis, type I (GDGDB) [GLB1]
          • GM1-gangliosidosis, type II (GDGDB) [GLB1]
          • GM1-gangliosidosis, type III (GDGDB) [GLB1]
          • Fabry disease (GDGDB) [GLA]
          • Gaucher disease, type IIIC (GDGDB) [GBA]
      • Eye Abnormalities
        • Gaucher disease, type IIIC (GDGDB) [GBA]
      • Lens Diseases
        • Cataract
          • Alpha-mannosidosis (GDGDB) [MAN2B1]
      • Ocular Hypertension
        • Glaucoma
          • Hurler syndrome (GDGDB) [IDUA]
          • Hurler-Scheie syndrome (GDGDB) [IDUA]
          • Scheie syndrome (GDGDB) [IDUA]
      • Retinal Diseases
        • Retinal Degeneration
          • Sialidosis (GDGDB) [NEU1]
            • Sialidosis type I [NEU1]
            • Sialidosis type II [NEU1]
              • Sialidosis type II, infantile form [NEU1]
              • Sialidosis type II, juvenile form [NEU1]
          • Galactosialidosis (GDGDB) [CTSA]
          • Hurler syndrome (GDGDB) [IDUA]
          • Mucopolysaccharidosis II (GDGDB) [IDS]
          • Mucopolysaccharidosis VII (GDGDB) [GUSB]
          • GM1-gangliosidosis, type I (GDGDB) [GLB1]
          • GM1-gangliosidosis, type II (GDGDB) [GLB1]
          • GM1-gangliosidosis, type III (GDGDB) [GLB1]
          • Tay-Sachs disease (GDGDB) [HEXA]
          • Sandhoff disease (GDGDB) [HEXB]
          • GM2-gangliosidosis, AB variant (GDGDB) [GM2A]
          • Krabbe disease (GDGDB) [GALC]
          • Metachromatic leukodystrophy (GDGDB) [ARSA]
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Niemann-Pick disease, type A (GDGDB) [SMPD1]
          • Farber Lipogranulomatosis (GDGDB) [ASAH1]
            • Farber Lipogranulomatosis, type 1 [ASAH1]
            • Farber Lipogranulomatosis, type 5 [ASAH1]
      • Optic Nerve Diseases
        • Optic Atrophy
          • Optic Atrophies, Hereditary
            • Combined saposin deficiency (GDGDB) [PSAP]
      • Ocular Motility Disorders
        • Gaucher disease, type II (GDGDB) [GBA]
        • Gaucher disease, type III (GDGDB) [GBA]
        • Gaucher disease, type IIIC (GDGDB) [GBA]
        • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Niemann-Pick disease, type C2 (GDGDB) [NPC2]