Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Central Nervous System Diseases'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Brain Diseases, Metabolic
            • Brain Diseases, Metabolic, Inborn
              • Aspartylglucosaminuria (GDGDB) [AGA]
              • Fucosidosis (GDGDB) [FUCA1]
              • Sialidosis (GDGDB) [NEU1]
              • Mucolipidosis II (alpha/beta) (GDGDB) [GNPTAB]
              • Mucolipidosis III (alpha/beta) (GDGDB) [GNPTAB]
              • GM1-gangliosidosis, type I (GDGDB) [GLB1]
              • GM1-gangliosidosis, type II (GDGDB) [GLB1]
              • GM1-gangliosidosis, type III (GDGDB) [GLB1]
              • Tay-Sachs disease (GDGDB) [HEXA]
              • Sandhoff disease (GDGDB) [HEXB]
              • GM2-gangliosidosis, AB variant (GDGDB) [GM2A]
              • Fabry disease (GDGDB) [GLA]
              • Gaucher disease, type II (GDGDB) [GBA]
              • Gaucher disease, type III (GDGDB) [GBA]
              • Gaucher disease, atypical, due to saposin C deficiency (GDGDB) [PSAP]
              • Krabbe disease (GDGDB) [GALC]
              • Multiple sulfatase deficiency (GDGDB) [SUMF1]
              • Metachromatic leukodystrophy (GDGDB) [ARSA]
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Niemann-Pick disease, type A (GDGDB) [SMPD1]
              • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
              • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
              • Farber Lipogranulomatosis (GDGDB) [ASAH1]
          • Dementia
            • Gaucher disease, type II (GDGDB) [GBA]
            • Gaucher disease, type III (GDGDB) [GBA]
            • Metachromatic leukodystrophy (GDGDB) [ARSA]
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
            • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
          • Intracranial Hypertension
            • Hydrocephalus
              • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Hurler syndrome (GDGDB) [IDUA]
              • Hurler-Scheie syndrome (GDGDB) [IDUA]
              • Scheie syndrome (GDGDB) [IDUA]
              • Mucopolysaccharidosis II (GDGDB) [IDS]
              • Sanfilippo syndrome A (GDGDB) [SGSH]
              • Sanfilippo syndrome B (GDGDB) [NAGLU]
              • Sanfilippo syndrome C (GDGDB) [HGSNAT]
              • Sanfilippo syndrome D (GDGDB) [GNS]
              • Mucopolysaccharidosis VI (GDGDB) (GDGDB) [ARSB]
              • Mucopolysaccharidosis VII (GDGDB) [GUSB]
          • Cerebrovascular Disorders
            • Stroke
              • Fabry disease (GDGDB) [GLA]
        • Movement Disorders
          • Dyskinesias
            • Aspartylglucosaminuria (GDGDB) [AGA]
            • Fucosidosis (GDGDB) [FUCA1]
            • Sialidosis (GDGDB) [NEU1]
            • Sanfilippo syndrome A (GDGDB) [SGSH]
            • Sanfilippo syndrome B (GDGDB) [NAGLU]
            • Sanfilippo syndrome C (GDGDB) [HGSNAT]
            • Sanfilippo syndrome D (GDGDB) [GNS]
            • Tay-Sachs disease (GDGDB) [HEXA]
            • Sandhoff disease (GDGDB) [HEXB]
            • Gaucher disease, type II (GDGDB) [GBA]
            • Krabbe disease (GDGDB) [GALC]
            • Metachromatic leukodystrophy (GDGDB) [ARSA]
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
            • Niemann-Pick disease, type A (GDGDB) [SMPD1]
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
            • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
            • Combined saposin deficiency (GDGDB) [PSAP]
        • Spinal Cord Diseases
          • Spinal Cord Compression
            • Hurler syndrome (GDGDB) [IDUA]
            • Hurler-Scheie syndrome (GDGDB) [IDUA]
            • Scheie syndrome (GDGDB) [IDUA]
            • Mucopolysaccharidosis II (GDGDB) [IDS]
            • Morquio syndrome A (GDGDB) [GALNS]
            • Morquio syndrome B (GDGDB) [GLB1]
            • Mucopolysaccharidosis VI (GDGDB) (GDGDB) [ARSB]
            • Mucopolysaccharidosis VII (GDGDB) [GUSB]
        • Ocular Motility Disorders
          • Gaucher disease, type II (GDGDB) [GBA]
          • Gaucher disease, type III (GDGDB) [GBA]
          • Gaucher disease, type IIIC (GDGDB) [GBA]
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
          • Niemann-Pick disease, type C2 (GDGDB) [NPC2]
          • Combined saposin deficiency (GDGDB) [PSAP]