Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Multiple sulfatase deficiency'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation
  • Disorders of sphingolipid metabolism and other lipid storage disorders
    • Sphingolipidosis
      • Other sphingolipidosis
        • Sulfatidosis
          • Multiple sulfatase deficiency (GDGDB) [SUMF1]

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Digestive System Diseases
      • Liver Diseases
        • Hepatomegaly
          • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Hemic and Lymphatic Diseases
      • Lymphatic Diseases
        • Splenic Diseases
          • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Musculoskeletal Diseases
      • Bone Diseases
        • Spinal Diseases
          • Spinal Curvatures
            • Kyphosis
              • Multiple sulfatase deficiency (GDGDB) [SUMF1]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • Multiple sulfatase deficiency (GDGDB) [SUMF1]
        • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Brain Diseases, Metabolic
            • Brain Diseases, Metabolic, Inborn
              • Multiple sulfatase deficiency (GDGDB) [SUMF1]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • Multiple sulfatase deficiency (GDGDB) [SUMF1]
        • Sensation Disorders
          • Hearing Disorders
            • Hearing Loss
              • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Hearing Disorders
          • Hearing Loss
            • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Pathological Conditions, Signs and Symptoms
      • Signs and Symptoms
        • Mobility Limitation
          • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Skin and Connective Tissue Diseases
      • Skin Diseases
        • Skin Abnormalities
          • Ichthyosis
            • Multiple sulfatase deficiency (GDGDB) [SUMF1]
    • Stomatognathic Diseases
      • Stomatognathic System Abnormalities
        • Maxillofacial Abnormalities
          • Multiple sulfatase deficiency (GDGDB) [SUMF1]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • Multiple sulfatase deficiency (GDGDB) [SUMF1]