Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Niemann-Pick disease, type C1'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation
  • Disorders of sphingolipid metabolism and other lipid storage disorders
    • Sphingolipidosis
      • Other sphingolipidosis
        • Niemann-Pick disease
          • Niemann-Pick disease, type C
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Digestive System Diseases
      • Liver Diseases
        • Hepatomegaly
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Eye Diseases
      • Ocular Motility Disorders
        • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Hemic and Lymphatic Diseases
      • Lymphatic Diseases
        • Splenic Diseases
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Brain Diseases, Metabolic
            • Brain Diseases, Metabolic, Inborn
              • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
          • Dementia
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Movement Disorders
          • Dyskinesias
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Ocular Motility Disorders
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
      • Neurologic Manifestations
        • Dyskinesias
          • Ataxia
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
          • Dystonia
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
          • Tremor
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
            • Learning Disorders
              • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
          • Intellectual Disability
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Paralysis
          • Facial Paralysis
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Seizures
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Otorhinolaryngologic Diseases
      • Pharyngeal Diseases
        • Deglutition Disorders
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Hyperbilirubinemia
          • Jaundice
            • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
      • Signs and Symptoms
        • Mobility Limitation
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Respiratory Tract Diseases
      • Lung Diseases
        • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
      • Respiration Disorders
        • Dyspnea
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
      • Respiratory Tract Infections
        • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
  • Psychiatry and Psychology
    • Behavior and Behavior Mechanisms
      • Behavior
        • Behavioral Symptoms
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Feeding and Eating Disorders of Childhood
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Motor Skills Disorders
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Intellectual Disability
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]
        • Learning Disorders
          • Niemann-Pick disease, type C1 (GDGDB) [NPC1]