Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Beta-mannosidosis'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation
  • Disorders of glycoprotein metabolism
    • Defects in glycoprotein degradation
      • Mannosidase deficiency diseases
        • Beta-mannosidosis (GDGDB) [MANBA]

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Musculoskeletal Diseases
      • Bone Diseases
        • Bone Diseases, Developmental
          • Dysostoses
            • Beta-mannosidosis (GDGDB) [MANBA]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • Beta-mannosidosis (GDGDB) [MANBA]
    • Neoplasms
      • Neoplasms by Histologic Type
        • Neoplasms, Vascular Tissue
          • Angiokeratoma
            • Beta-mannosidosis (GDGDB) [MANBA]
    • Nervous System Diseases
      • Neuromuscular Diseases
        • Peripheral Nervous System Diseases
          • Beta-mannosidosis (GDGDB) [MANBA]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • Beta-mannosidosis (GDGDB) [MANBA]
          • Intellectual Disability
            • Beta-mannosidosis (GDGDB) [MANBA]
        • Neuromuscular Manifestations
          • Muscle Hypotonia
            • Beta-mannosidosis (GDGDB) [MANBA]
        • Seizures
          • Beta-mannosidosis (GDGDB) [MANBA]
        • Sensation Disorders
          • Hearing Disorders
            • Hearing Loss
              • Beta-mannosidosis (GDGDB) [MANBA]
          • Somatosensory Disorders
            • Hypesthesia
              • Beta-mannosidosis (GDGDB) [MANBA]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Otitis
          • Beta-mannosidosis (GDGDB) [MANBA]
        • Hearing Disorders
          • Hearing Loss
            • Beta-mannosidosis (GDGDB) [MANBA]
      • Pharyngeal Diseases
        • Deglutition Disorders
          • Beta-mannosidosis (GDGDB) [MANBA]
    • Respiratory Tract Diseases
      • Respiratory Tract Infections
        • Beta-mannosidosis (GDGDB) [MANBA]
    • Stomatognathic Diseases
      • Stomatognathic System Abnormalities
        • Maxillofacial Abnormalities
          • Beta-mannosidosis (GDGDB) [MANBA]
  • Psychiatry and Psychology
    • Behavior and Behavior Mechanisms
      • Behavior
        • Behavioral Symptoms
          • Child Reactive Disorders
            • Beta-mannosidosis (GDGDB) [MANBA]
          • Depression
            • Beta-mannosidosis (GDGDB) [MANBA]
          • Beta-mannosidosis (GDGDB) [MANBA]
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Motor Skills Disorders
          • Beta-mannosidosis (GDGDB) [MANBA]
        • Intellectual Disability
          • Beta-mannosidosis (GDGDB) [MANBA]