Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Krabbe disease'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation
  • Disorders of sphingolipid metabolism and other lipid storage disorders
    • Sphingolipidosis
      • Other sphingolipidosis
        • Krabbe disease (GDGDB) [GALC]
          • Krabbe disease, infantile form [GALC]
          • Krabbe disease, late-onset form [GALC]

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Eye Diseases
      • Retinal Diseases
        • Retinal Degeneration
          • Krabbe disease (GDGDB) [GALC]
    • Musculoskeletal Diseases
      • Muscular Diseases
        • Muscle Rigidity
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
            • Krabbe disease, late-onset form [GALC]
        • Muscle Weakness
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
            • Krabbe disease, late-onset form [GALC]
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Brain Diseases, Metabolic
            • Brain Diseases, Metabolic, Inborn
              • Krabbe disease (GDGDB) [GALC]
        • Movement Disorders
          • Dyskinesias
            • Krabbe disease (GDGDB) [GALC]
      • Demyelinating Diseases
        • Hereditary Central Nervous System Demyelinating Diseases
          • Krabbe disease (GDGDB) [GALC]
      • Neuromuscular Diseases
        • Peripheral Nervous System Diseases
          • Krabbe disease (GDGDB) [GALC]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Intellectual Disability
            • Krabbe disease (GDGDB) [GALC]
        • Neuromuscular Manifestations
          • Muscle Hypertonia
            • Muscle Rigidity
              • Krabbe disease (GDGDB) [GALC]
                • Krabbe disease, infantile form [GALC]
                • Krabbe disease, late-onset form [GALC]
          • Muscle Weakness
            • Krabbe disease (GDGDB) [GALC]
              • Krabbe disease, infantile form [GALC]
              • Krabbe disease, late-onset form [GALC]
        • Seizures
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
            • Krabbe disease, late-onset form [GALC]
        • Sensation Disorders
          • Hearing Disorders
            • Hearing Loss
              • Krabbe disease (GDGDB) [GALC]
                • Krabbe disease, infantile form [GALC]
                • Krabbe disease, late-onset form [GALC]
          • Vision Disorders
            • Blindness
              • Krabbe disease (GDGDB) [GALC]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Hearing Disorders
          • Hearing Loss
            • Krabbe disease (GDGDB) [GALC]
              • Krabbe disease, infantile form [GALC]
      • Pharyngeal Diseases
        • Deglutition Disorders
          • Krabbe disease (GDGDB) [GALC]
    • Pathological Conditions, Signs and Symptoms
      • Signs and Symptoms
        • Body Temperature Changes
          • Fever
            • Krabbe disease (GDGDB) [GALC]
              • Krabbe disease, infantile form [GALC]
        • Mobility Limitation
          • Krabbe disease (GDGDB) [GALC]
    • Respiratory Tract Diseases
      • Respiration Disorders
        • Dyspnea
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
        • Respiratory Insufficiency
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
        • Feeding and Eating Disorders of Childhood
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
        • Motor Skills Disorders
          • Krabbe disease (GDGDB) [GALC]
            • Krabbe disease, infantile form [GALC]
        • Intellectual Disability
          • Krabbe disease (GDGDB) [GALC]